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Thursday, 6 December 2018

New hope for stem cell therapy in patients with leukemia

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New hope for stem cell therapy in patients with leukemia

Of the many different kinds of cancer that affect humans, leukemia is the most common in young people. As with many types cancer, doctors mostly turn to chemotherapy to treat patients. Chemotherapy, however, comes with its own share of issues, primarily severe side effects and the constant threat of disease recurrence.

Stem cell therapy treatment has emerged as a potential cure for some types of cancer, with leukemia patients being among the first groups of patients to receive this type of treatment. While exciting because of the possibility of a complete cure, stem cell therapy comes with its own challenges. Let’s take a closer look.

Leukemia is characterized by abnormal white blood cells (also known as the many different types of cells that make up our immune system) that are produced at high levels. Stem cell therapy is such an appealing treatment option because it involves replacing the patient’s aberrant blood stem cells with healthy ones from a donor, which provides the possibility of complete and permanent remission for the patient.

Unfortunately, in approximately half of patients who receive this therapy, the donor cells (which turn into immune cells), can also destroy the patients healthy tissue (i.e. liver, skin etc…), because the transplanted blood stem cells recognize patient’s tissue as foreign. While doctors try to lessen this type of response (also known as graft versus host disease (GVHD)), by suppressing the patient’s immune system, this procedure lessens the effectiveness of the stem cell therapy itself.

Now scientists at the University of Zurich have made an important discovery – published in the journal Science Translational Medicine – that could mitigate this potentially fatal response in patients. They found that a molecule called GM-CSF, is a critical mediator of the severity of GVHD. Using a mouse model, they showed that if the donor cells were unable to produce GM-CSF, then mice fared significantly better both in terms of less damage to tissues normally affected by GVHD, such as the skin, and overall survival.

While exciting, the scientists were concerned about narrowing in on this molecule as a potential target to lessen GVHD, because GM-CSF, an important molecule in the immune system, might also be important for ensuring that the donor immune cells do their jobs properly. Reassuringly, the researchers found that blocking GM-CSF’s function had no effect on the ability of the donor cells to exert their anti-cancer effect. This was surprising because previously the ability of donor cells to cause GVHD, versus protect patients from the development of cancer was thought to occur via the same biological mechanisms.

Most excitingly, however, was that finding that high levels of GM-CSF are also observed in patient samples, and that the levels of GM-CSF correlate to the severity of GVHD. Dr. Burkhard Becher and his colleagues, the authors of this study, now want to run a clinical trial to determine whether blocking GM-CSF blocks GVHD in humans like it does in mice. In a press release, Dr. Becher states the importance of these findings:

If we can stop the graft-versus-host response while preserving the anti-cancer effect, this procedure can be employed much more successfully and with fewer risks to the patient. This therapeutic strategy holds particular promise for patients with the poorest prognosis and highest risk of fatality

Monday, 3 December 2018

Know The Basics Before You Undergo IVF

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In Vitro fertilization treatment India is the fertilization found in the woman’s egg after coming in contact with man’s sperm in the lab. Since it is carried out in the lab in a glass tube it is also called as a test tube baby. The procedure among the couples are seen undergoing through the infertility issue. The treatment started with the medicines fixing the hormones that helps in stimulating the ovaries of the woman to make the eggs mature. The In Vitro Fertilization treatment India is known for its high success rate as it come along with high quality. Thus it is the best IVF success rate that comes into the picture and thus make the family for the childless couple.

In Vitro Fertilization treatment India

Understanding Infertility:

A couple despite having all the physical relationship for not less than a year if is unable to conceive is known as the infertile. There could be a wide range of factors that are responsible in giving this issue but thanks to the presence of the best treatment options like In Vitro Fertilization treatment India, these issues can be fixed and one can get rid of the same to have the baby. As per reports one third of the couple are seen suffering from this issue and then end up giving the best of the results.

Types of Infertility Treatment Options: 

When it comes to the infertility treatment options, there are several options that offer the best IVF fertilization treatment India.

Some of these are indicated as under:

  • In vitro fertilization 
  • Micro-insemination sperm transfer 
  • Sub-zonal insemination 
  • Intracytoplasmic sperm injection 
  • Zygote intra-fallopian transfer 
  • Gamete intra-fallopian transfer 
  • Testicular sperm extraction 
  • Micro-epididymal sperm aspiration 

The Good Candidate for IVF Procedure:

The In Vitro Fertilization treatment India though can treat only the women with issues like tubal ailments, the IVF can help in overcoming the different types of infertility particularly the couples having less success rate and invasive infertility treatment options. The couple who have not tried the treatment options like the IVF and other becomes the candidate for the same.

Some of the couples who have the following issues eventually become the good candidate for the IVF procedure:

  • Damaged or Blocked fallopian tubes
  • Endometriosis 
  • Pelvic inflammatory disease
  • Male factor infertility
  • Polycystic Ovarian Syndrome (PCOS)
  • Cervical mucus problems
  • Unexplained infertility
  • Genetic diseases 
  • Ovulation disorders
  • Low sperm count or other sperm problems
  • At least one accessible ovary
  • A normal uterus 

What are the Benefits of IVF Treatment?

The In Vitro Fertilization treatment India happens to be the major treatment option which bring in a sea of benefits for the childless couple.

Some of the key benefits one can gain while opting for this surgery include the following:

  • One of the most apparent benefits of IVF treatment is that it helps in  fixing the infertile couple for having a baby. Both men and women who seem to suffer from different infertility issues  can be seen successfully undergoing IVF treatment 
  • The women within the 35 years of age can have the best IVF success rate for women in their late thirties and forties are seen having the issue for the same
  • This treatment option can also offer the women with blocked and damaged fallopian tubes too can get the option of getting treated the best with this treatment option
  • The high or best IVF success rate for the treatment is also an another benefit one can gain with the surgery
  • The donor sperm or eggs can be fixed with this treatment option which is also one of the key benefits one can enjoy with it
  • The donor sperm and eggs are at times used for the other benefit that can be the other benefit to enjoy with this treatment option
In this way, the In Vitro Fertilization treatment India can have loads of benefits to reap.

Monday, 26 November 2018

Highest Success Rate of IVF in India Relying On Any Best IVF Doctor Assures Better Results

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What Is Infertility?

Infertility is all about a biological inability of anyone to allow conception. It is a condition in which couples looking for child faces problems in conceiving after a year or so despite the regular physical relations without relying on any birth control methods. However, seeking the help of any best IVF doctor in India global patients are fixing the problem of Infertility. They are getting the highest success rate of IVF in India. 

What Are The Types Of Infertility?

Before you consult any best IVF doctor in India, you need to check the types of this ailment. Depending upon the type and issues involved in it would define the success rate of it and you would understand the highest success rate of IVF in India. Well, let’s check the types:  
  • Primary Infertility
  • Secondary Infertility
  • Subfertility
  • Male Infertility
  • Female Infertility
Once you find out the type you can proceed with the required treatment for your infertility issue.

How Is Infertility Diagnosed And Popular Treatments Used For It?

Once you find that you are the victim of infertility then you need to know how it is diagnosed. Well, it is simple, these are diagnosed by conducting a series seeking the help of a best IVF doctor in India, which are enclosed as under: 
  • Blood Tests
  • Ultrasound Examination
  • Semen Analysis
When it comes to the popular treatments used to fix the issue of Infertility giving highest success rate of IVF in India, these can be categorised into three different categories as under:
  • The Medicines that helps in Improving Fertility
  • The Surgical Treatments
  • The Assisted Conception

Assisted Reproductive Technology, Or ART. There Are Different Types Of ART:

  1. IUI (Intrauterine Insemination): Intrauterine Insemination treatment is done by placing sperm in the uterus. It is done with the help of a thin tube, which is passed into the Uterus, via the Cervix. Then, sperms are passed through the tube. The Fallopian Tubes have to be healthy for complete success of this procedure. 
  2. IVF (In Vitro Fertilization): This method is helpful for couples, where the exact reason behind Infertility cannot be fathomed or if the female has blocked Fallopian Tubes. The candidates are given fertility medications to stimulate the Ovaries to get more eggs than the usual. The next step is where the eggs are retrieved by a small surgery and kept on a laboratory dish for a few days, till the eggs form embryos. 
  3. GIFT (Gamete Intrafallopian Transfer): In this technique, sperm and eggs are collected in the same manner like in IVF. Then they are mixed and placed into any of the two Fallopian Tubes. This method is implemented as men’s Infertility treatment and also for unexplained causes of Infertility.

How Is Life After Infertility Treatment?

Life after the treatment is always cool and you often get the highest success rate of IVF in India making your time of despair go away. If you are among the lucky couples and have relied on any best IVF doctor in India then you would get the positive result. The feeling of excitement and happiness will retain for years and you would enjoy the bliss of having the baby at the set time period. 

What Are The Benefits Of Infertility Treatment?

The benefits of getting the treatment are many provided you rely on any best IVF doctor in India. With this you get the blessing of getting a child and enjoying the highest success rate of IVF in India. You get rid of the stigma of being childless and gain your self-confidence and happiness with it. 

How Is Infertility Treatment In India?

The infertility treatment in India is one of the option to consider. This is because it comes with the best results. The highest success rate of ivf in India therefore attract the global patients. This is due to the presence of the best IVF doctor in India and the best hospitals for this ailment.

What Is The Success Rate Of IVF?

The success rate would depend on factors like medical conditions, the choice of any best IVF doctor in India, hospital and other things, which goes up to 90 percent in most of the cases reported to the infertility experts. 

Why Choose Us?

The reasons are many, we are the best and have been into this domain more than a decade giving affordable package backed with quality. We have the best IVF doctor in India and hospitals in our network. These promise the highest success rate of IVF in India, while we take care of other things like local travel, stay, food, support to get the medical visa, etc.

If you wish to plan your medical treatment in India then you can get quick appointment Call on: +91-9370586696 OR Email on:

Go through the website and fill all the required details in the enquiry form the team will get back to with all the information within 24 hours

For more details visit our website

Friday, 24 August 2018

Treating lymphoma in a pocket size budget: Lymphoma treatment in Delhi

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What is Lymphoma? 

When the white blood cells known to be the fighter cell of the body develop cancer is termed as lymphoma. It is a type of cancer starts in the white blood cells, or lymphocytes. As it is present in the bloodstream, it can spread, or metastasize, to different parts of the body. It is one of the most common cancers in children age group between 15-24 ages but it is not limited to a particular age.

Treating lymphoma in a pocket size budget: Lymphoma treatment in Delhi

What are the different types of Lymphoma treatment available?

The broad term lymphoma which starts from cells of lymphatic system is broadly differentiated into two types:  
  1. Hodgkin lymphoma: Infection with EBV can cause mononucleosis, which increases the risk of lymphoma. People with 20-30 age groups and over the age of 55 are most likely to be affected. Hodgkin lymphoma is most common in the U.S., Canada, and northern Europe. It is least common in Asia. If a sibling has this lymphoma the risk is high and if those are identical twins then it is more likely that both will develop lymphoma. HIV can weaken the immune system and increases the risk of lymphoma. 
  2. Non-Hodgkin lymphoma: Mostly occur in people above the age of 60. African-Americans and Asian-Americans are at lower risk of non-Hodgkin lymphoma than white Americans. People with a weak immune system are more at risk. Some chemicals used in agriculture and the radiations caused by them have been linked to non-Hodgkin lymphoma. Epstein-Barr virus (EBV) which causes glandular fever transforms lymphocytes and increases the risk of lymphoma. Obesity has been implicated in the development of lymphoma.

How much does it cost for Lymphoma treatment in Delhi? 

India is known for its cost-effective and best medical facility services. Lymphoma treatment in Delhi is one the most valued medical service in India. There several lymphoma specialist in Delhi working on different ways to fight lymphoma and planning research toward the substantial goal.  The cost of lymphoma at best hospital for lymphoma treatment in Delhi starts from $5,000

Success story of Brazil Patient visited Delhi for lymphoma treatment:

Lucas Silva was diagnosed with Non-Hodgkin lymphoma in year 2000 at the age of 30. Back then he was facing severe pain and that got only worse with time and but didn’t go away.” you know you need to see a doctor when you feel that way, hence without wasting more time I went straight to my family doctor” eventually after some CT scans it was confirmed that he has developed a tumor and doctor told him that it was treatable. Mr. Silva landed up in one of the best hospital for lymphoma treatment in Delhi in search of affordable treatments in India.  He had chemotherapy and radiation, and wound up spending a lot of time with other people in hospital along the way. Mr. Silva says that he is lucky to know these people and being able to experience something that we may never want to catch up in. it has taught him a lot and now that he is all content and happy for the second chance he is living it even better than he ever was. “Lymphoma treatment in Delhi is one of the best service providers anyone could find in terms of cost and facilities and I’m glad that I found one in my hard time”

Why choose Indian Med Guru for consultation about lymphoma treatment in Delhi?

Indian Med Guru are one of the best healthcare service providers. They will guide you every step of the way from quick visa letters to hotel arrangements and booking appointments with lymphoma specialists in Delhi. That will give you with an access to the world’s best medical facilities with several budget-friendly packages and are also affordable to people from all parts of the globe. 

Get Free opinion, Quote, Medical Visa Invitation and Assistance at every step of your the treatment in India. You can call us +91-9370586696 and you can email us

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Watch the video of Lymphoma Treatment in Delhi with Indian Med Guru Consultants

Monday, 2 July 2018

Your Happiness is Crucial To Dr. Firuza Parikh Providing The Most Modern Infertility Treatment in India

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IVF is a process, used to conquer number fertility issues, by way of which an egg and sperm are joined collectively outside the body, in a specialised laboratory. The fertilised egg is allowed to grow in a protected environment for a few days earlier than being transferred into the women uterus increasing the chance that a pregnancy will occur.

Dr. Firuza parikh Best infertility specialist in mumbai
Dr. Firuza Parikh best infertility specialist in Mumbai 

IVF with Dr. Firuza Parikh at Jaslok Hospital:

Dr Firuza Parikh, director of assisted reproduction and genetics at Jaslok Hospital and Research Center in Mumbai, has been responsible for the births of 5000 ART babies. Dr. Firuza Parikh Best infertility specialist in Mumbai has lost count now, she has been working with IVF and other procedures for over 20 years, bringing hope to infertile couples. She offers a completely unique method to the problem of infertility. Her numerous distinct qualities have enabled her to provide the excellent viable care for couples managing fertility troubles. She offers personalized care that is tailored to each patient’s individual needs. She cares deeply about her patients, and would like to help you build a beautiful family. So, go ahead and get to know her better.

To know more about IVF treatment for domestic and international patient please email us today or phone +91-9370586696 

90% infertility cases can be treated: Dr. Firuza Parikh: 

Approximately 10-15% of couples struggle with conceiving .There are numerous reasons as to why a woman may struggle to conceive. Medical situations, hormone irregularities, or abnormalities of the reproductive organs can all affect fertility. Dr Firuza Parikh famous IVF specialist at Jaslok hospital will assess your medical history and try to identify suspect causes, as well as perform a physical exam and series of blood tests, in order to find a cause and appropriate solution.

Success story of IVF treatment under Dr. Firuza Parikh:

“I am George 31 years old male and wife Ava is 29. We live in UK and today I take this opportunity to jot down our long and tiring story of parenthood via IVF and how Dr. Firuza Parikh IVF specialist in Mumbai came in our life wearing a white Doctor's coat. After 3 failed IUIs, and 1 failed IVF, painful process of egg retrieval followed by failed IVF after losing false positive hopes multiple times, this was the time when we stumbled upon Dr. Firuza Parikh at Jaslok Hospital and Research Centre in Mumbai, India.  We have met many 'best infertility' doctors by now, but she was out-of-the-box approach, ability to connect-the-dots was so impressive that our confidence towards parenthood started to re-build. We followed everything she said, like a holy grail, because we understood that we are in the safest hands. And It paid well, By end of Jan'18 my wife is pregnant, continuing well and our due-date is in Sept'18. Thanks to genuinely wonderful, talented and caring human being for helping us with this miracle and blessing in our lives.”

Why choose Dr. Firuza Parikh for IVF treatment in Mumbai?

Dr. Firuza Parikh best obstetrics and gynaecologist in India, a sophisticated facility utilizes modern and advance techniques for infertility treatment.  Till date, she has 1000+ successful IVF treated cases with best success rate. She offers a unique approach to the problem of infertility. With years of experience in and an established practice, she has numerous distinct qualities that allow her to offer the fine possible care of couples managing fertility problems.

What is the process for abroad patients fix an appointment with Dr. Firuza Parikh:

If you have had difficulty to conceive and thinking about treatment, she can provide precious information to assist, make this a greater informed and hopefully a successful journey. We have a division dedicated to international patients that specifically looks into all queries from the foreign couples. This facility is provided for all overseas patients to make them avail an initial online consultation before they come to India for treatment. This helps to reduce treatment the duration of treatment in Mumbai thus saving precious time. Dr. Firuza Parikh best infertility specialist in Mumbai has significant number of patients consulting them on fertility issues and solutions from UK, UAE, USA, Australia and Africa.

Why choose Indian Med Guru Consultants?

The key to success is the patient and clinical coordination and Indian Med Guru consultant ensures this right at the onset. The reasonable and affordable packages are not the only reasons why international patients are being routed through Indian Med Guru consultant. With an enhanced self confidence, most people leave the clinics with renewed esteem and compliments. 

Book an Appointment with Dr. Firuza Parikh best famous IVF specialist at Jaslok Hospital, Mumbai on +91-9370586696

Friday, 15 June 2018

What women need to know about Uterine Fibroid?

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Before we discuss the uterine fibroid surgery cost or the treatment of the same with fibroid surgery, we need to know about the same. Well, the fibroid can be defined as the non-cancerous tumors that are seen growing over the muscle layers seen over the uterus. In the rare cases, you can find them becoming cancerous. As per reports, more than 20 per cent ladies with child bearing capacities are seen getting affected by this problem. We can find women often of 30 to 50 having the problem of fibroid in their uterus that need the medical attention. More often the obese and overweight women are seen having at the higher risk of developing the fibroid when compared to the ladies with normal weight. The cancerous growths of the smooth muscles inside the womb are seen getting developed known as the leiomyosarcoma inside the womb but this case is often rare that would further demand for fibroid surgery.

Causes of Fibroid:

The fibroid is seen starting up with a single muscle cell over the uterus. The exact reasons are still unknown; however, there are certain causes that bring this problem. Some of the reasons behind the same include the cell changes taking place in the fibroid tumor cells that are seen starting up to grow and then multiply. At times the heredity could be the reason behind the same. As per experts it’s the muscle cells that are programmed in a particular way to form the fibroid over the uterus that can remain during the puberty phase as well. The puberty are seen producing more hormones particularly the estrogen that at times would grow a lot and can make things happen.

Symptoms of Fibroid:

The symptoms of fibroid are several and some of these are indicated as under: 
  • Heavy Vaginal Bleeding 
  • Pelvic Discomfort 
  • Pelvic Pain 
  • Bladder Problems 
  • Low Back Pain 
  • Rectal Pressure 
  • Discomfort or Pain with Sexual Intercourse 

So, if you are experience these symptoms it is recommend seeing the doctor you can book your online consultation to know about fibroid surgery now; call on:+91-9370586696 

Fibroid Surgery and Treatment options:

When it comes to fibroid surgery and treatment options, there are several methods to consider. So, once you find the medications failing to work then only resort comes in the form of a fibroid surgery, which is indicated as under:
  • Hysterectomy 
  • Myomectomy 
  • Uterine Fibroid Embolization (UFE) 
  • Endometrial Ablation 
  • Magnetic Resonance Guided Percutaneous Laser Ablation 
  • Magnetic Resonance Guided Focused Ultrasound Surgery 

Besides these there are several advanced surgical procedures found for the fibroid treatment, which are as under: 
  • Embolization 
  • Laparoscopic Surgery 
  • Hysteroscopic Resection 

Success Rate of Fibroid Surgery:

When it comes to the success rate for fibroid surgery there are several factors that play the role in fixing things. Some of these include the choice of surgeon, the hospital and the medical team. Choosing high end hospitals and competitive doctor may boost up the uttering fibroid surgery cost to some extent but the success rate rises up. Generally speaking with competitive factors like these the success rate often shoots up to even 99 to 100 percent.

Why Indian Med Guru for Fibroid Surgery?

Fibroid Surgery, uterine fibroid surgery cost. There are many reasons to consider the group Indian Med Guru group for fibroid surgery package in the Indian hospitals. One of the basic reasons to consider the affordable uterine fibroid surgery cost packages with quality healthcare services along with getting a wide range of other factors. The group has best doctors and surgeons along with top hospitals and clinics that give you the best results. Besides, the group has a wide range of services to offer. You have a number of other services to avail with the healthcare services, which include quality your local stay, food, travel and help in getting the medical visa.

We pride ourselves on our level of patient care, we have 24*7 online consultation available for our patient’s one can get in touch with us by calling on: +91-9370586696 OR can mail there detailed reports on:

Thursday, 31 May 2018

Dr. Rajesh Sharma the Best Children's Cardiac Surgeon, Leading The Way in India

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Heart surgical treatment in children are indicated to restore heart defects a infant is born with CHD (congenital coronary heart defects) and coronary heart diseases a toddler gets after birth. The surgery is needed for the child's well being. There are many kinds of heart defects ranging from minor to serious. Some heart defects may need surgery right after the baby is born and for few defects the surgery can wait.  Certain heart defects may not need repair as they can heal as the baby grows.

Dr. Rajesh Sharma Heart Surgeon

Dr. Rajesh Sharma Heart Surgeon

World-class paediatric heart care right here right now with Dr. Rajesh Sharma

The smallest patients require the most compassionate care. Dr. Rajesh Sharma provides children with the most effective, highest quality cardiovascular care in the world. Whenever possible, he chooses minimally invasive procedures. In the event that a more invasive approach is required, he uses clinically advanced best practices to reduce risk and prevent infection. Dr. Rajesh Sharma Heart Surgeon realizes this is a highly stressful time for parents. He communicates with family members regularly to keep them up-to-date on the status of their child. He has earned distinction in pediatric cardiovascular cath lab interventions and the care of complicated cardiac conditions by means of attaining tiers of excellence in pediatric cardiac interventions he have performed more than 1,000 diagnostic catheterization procedures for the evaluation of simple and complex congenital heart disease and pulmonary hypertension.

To get online consultation with Dr. Rajesh Sharma Best Heart Doctor in India
Mail us on: OR call on: +91-9860755000

Success Story of David who underwent cardiac surgery with Dr. Rajesh Sharma Best Paediatric Cardiac Surgeon in Delhi

“Our Baby was born on January 1, 2017. It was one of the happiest days of our lives. My wife and I were so glad everything had gone well and our baby was beautiful. David was born at 7 pounds, 7 ounces and 21 inches.  I received a phone call from my doctor. She told me that the baby had a problem with his heart. All of my blood rushed to my feet and I thought I was going to pass out. But I hung up the phone, grabbed my other son and went back to the hospital. 

I was been told that David had a hole in his heart and that the artery that feeds blood to the lungs was partially blocked. The medical term for this is Tetralogy of Fallot. Although David felt fine, we certainly did not want to put his health at risk. Where a good friend recommended that we see Dr. Rajesh Sharma, a cardiologist in India. When we searched on Google for him for more information we found that he is one of the eminent pediatric cardiothoracic surgeons of Delhi who has accomplished recognition for his expertise and experience. He is the director and the pediatric cardiothoracic surgeon at Fortis Escorts Heart Institute in New Delhi. He has carried out over 20,000 cardiac surgical techniques in his career, which created for both the adult and congenital coronary heart disease.

 We went to see him at the first opportunity, armed with all his test results. He conducted further tests, and he uttered the three words which we did not want to hear: Your child needs surgery. So we decided to go ahead with the surgery, after the surgery Dr. Rajesh Sharma came out to let us know how the surgery went. He told us that David had a hole about the size of a nickel and that the surgery had gone very well. The words thank you do not seem like enough at a time like that, but it was all we could say. Our baby was fine thanks to the caring effort of his surgeon who took so good care of our baby.”

Arabic Nationals can avail the service visit: أفضل جراح قلب للأطفال في دلهي

Why choose Indian Med Guru Consultants?

Having established ourselves as one of the top medical provider, we have grown to understand the pulse of the industry. We combine the strengths of both sectors i.e., healthcare and tourism, to provide you with affordable, secure, and premium healthcare services in India. We are known for our professional approach and an empathetic attitude towards our patrons, thus ranking us amongst the top medical provider companies in the world. While maximum of our surgeons are well hooked up of their respective fields, most of them have over twenty years of experience and are qualified members of Medical boards in India. Indian Med Guru consultant takes care of all the requirements from the pre-treatment phase to the post-operative phase. Our team also helps organise trips tourist destinations that would be of interest to you.

We pride ourselves on our level of patient care, so if you would like more information or even if you have a simple question, please email us at:  or call on+91-9860755000 and we would be more than happy to help.